查这种产品:Exendin-4(美国Sigma公司生产的)说明书
发布网友
发布时间：2022-04-25 03:44
共1个回答
热心网友
时间：2023-10-11 22:55
E7144
Sigma Exendin-4
≥97%
Amino Acid SequenceHis-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
Molecular FormulaC184H282N50O60S
Molecular Weight4186.57
CAS Number141758-74-9
MDL number MFCD00240171
Expand/Collapse All
Price and Availability
Click For Pricing and Availability
Descriptions
Other Notes Originally isolated from Heloderma suspectum (Gila monster lizard) venom.
Biochem/physiol Actions Exendin-4, a 39 amino acid peptide, activates GLP-1 (glucagon-like peptide-1) receptors to increase intracellular cAMP in pancreatic acinar cells and has no effect on VIP receptors.
Properties
storage temp. −20°C
References
Reference Eng, J., et al., Isolation and characterization of exendin-4 an exendin-3 analogue from Heloderma suspectum venom. J. Biol. Chem. 267, 7402, (1992)
Singh, G., et al., Use of 125I-[Y39] exendin-4 to characterize exendin receptors on dispersed pancreatic acini and gastric chief cells from guinea pig. Regul. Pept. 53, 47, (1994)
Montrose-Rafizadeh, C., et al., High potency antagonists of the pancreatic glucagon-like peptide-1 receptor. J. Biol. Chem. 272, 21201-21206, (1997)
Beak, S.A., et al., Glucagon-like peptide-1 stimulates luteinizing hormone-releasing hormone secretion in a rodent hypothalamic neuronal cell line. J. Clin. Invest. 101, 1334-1341, (1998)
Related Categories
... Obesity Research > Exendin
... Toxins > Lizard
原文见参考资料链接：
参考资料：http://www.sigmaaldrich.com/catalog/search/ProctDetail?ProdNo=E7144&Brand=SIGMA
